Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
Genome Biol. 2009;10(12):R140. doi: 10.1186/gb-2009-10-12-r140. Epub 2009 Dec 10.
Recent technological breakthroughs have enabled high-throughput quantitative measurements of hundreds of thousands of genetic interactions among hundreds of genes in Saccharomyces cerevisiae. However, these assays often fail to measure the genetic interactions among up to 40% of the studied gene pairs. Here we present a novel method, which combines genetic interaction data together with diverse genomic data, to quantitatively impute these missing interactions. We also present data on almost 190,000 novel interactions.
最近的技术突破使得能够高通量定量测量数以万计的酿酒酵母中数以百计的基因之间的数十万种遗传相互作用。然而，这些测定方法往往无法测量多达 40%的研究基因对之间的遗传相互作用。在这里，我们提出了一种新方法，该方法将遗传相互作用数据与多种基因组数据相结合，对这些缺失的相互作用进行定量推断。我们还提供了近 19 万个新相互作用的数据。
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