Zoological Institute, Christian-Albrechts-University Kiel, Olshausenstrasse 40, 24098 Kiel, Germany.
Semin Immunol. 2010 Feb;22(1):54-8. doi: 10.1016/j.smim.2009.11.002. Epub 2009 Dec 11.
Molecular genetic evidence has revealed that the basic templates of innate immune sensors were laid down in ancient animals such as the cnidarian Hydra. Important functions of Hydra's innate immune sensors and effectors include not only protection against pathogens but also controlling tissue-microbiota homeostasis. The deep evolutionary connections imply that invertebrate and mammalian immune pathways have evolved from a reduced number of common ancestral building blocks to their present configurations.
分子遗传学证据表明，先天免疫传感器的基本模板是在古代动物（如水螅）中建立的。水螅先天免疫传感器和效应器的重要功能不仅包括抵御病原体，还包括控制组织微生物组的平衡。这种深刻的进化联系意味着无脊椎动物和哺乳动物的免疫途径是从少数共同的祖先模块进化而来的，最终形成了现在的结构。
