Park Seong Bae, Sung Kyung Rim, Kang Sung Yong, Kim Kyung Ri, Kook Michael S
Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, 388-1 Pungnap-2-dong, Songpa-gu, Seoul 138-736, Korea.
Arch Ophthalmol. 2009 Dec;127(12):1603-9. doi: 10.1001/archophthalmol.2009.296.
To compare the glaucoma diagnostic capabilities offered by Stratus and Cirrus spectral-domain optical coherence tomography (OCT).
One hundred subjects with glaucoma and 74 healthy subjects were tested by Stratus and Cirrus OCT. Areas under the receiver operating characteristic curves (AUCs) of average, 4-quadrant, and 12-sector retinal nerve fiber layer thicknesses and sensitivities at fixed specificities (80% and 90%) were compared when the 2 OCT modalities were used to evaluate patients with early or moderate to advanced glaucoma. Likelihood ratios using normative classifications were reported.
Overall, both OCT instruments showed similar glaucoma discrimination capability in average retinal nerve fiber layer thickness (AUC, 0.953 [Cirrus] vs 0.934 [Stratus]; P = .15). Cirrus OCT displayed significantly higher AUCs in the average, inferior, temporal, and superior quadrants and 7-o'clock measurements in early stages of glaucoma. The between-OCT instrument AUCs did not differ significantly in moderate to advanced stages. Abnormal results for both OCT instruments, after comparison with their normative databases, were associated with high likelihood ratios.
In our series, the Cirrus OCT showed better glaucoma discrimination capability than Stratus OCT in early stages of glaucoma. Our findings suggest that spectral-domain technology of OCT may offer an improved capability of early-stage glaucoma detection.
比较Stratus和Cirrus频域光学相干断层扫描（OCT）的青光眼诊断能力。
对100例青光眼患者和74例健康受试者进行Stratus和Cirrus OCT检测。当使用这两种OCT模式评估早期或中度至重度青光眼患者时，比较平均、4象限和12扇区视网膜神经纤维层厚度的受试者操作特征曲线下面积（AUC）以及固定特异性（80%和90%）时的敏感度。报告使用规范分类的似然比。
总体而言，两种OCT仪器在平均视网膜神经纤维层厚度方面显示出相似的青光眼鉴别能力（AUC，Cirrus为0.953，Stratus为0.934；P = 0.15）。在青光眼早期，Cirrus OCT在平均、下方、颞侧和上方象限以及7点钟测量中显示出显著更高的AUC。在中度至重度阶段，两种OCT仪器之间的AUC没有显著差异。与各自的规范数据库比较后，两种OCT仪器的异常结果都与高似然比相关。
在我们的研究系列中，Cirrus OCT在青光眼早期显示出比Stratus OCT更好的青光眼鉴别能力。我们的研究结果表明，OCT的频域技术可能提供更好的早期青光眼检测能力。
