Cánovas-Serrano Yaiza, Vallés-San-Leandro Lorenzo, Rodríguez-Izquierdo Miguel Ángel, López-Serrano Rafael, Lajara-Blesa Jerónimo
Health Sciences PhD program, Catholic University of Murcia (UCAM), Campus de los Jerónimos n°135, Guadalupe 30107, Murcia, Spain.
Clinical Research Department, Vista Ircovisión, Murcia, Spain.
J Optom. 2023 Jan-Mar;16(1):81-87. doi: 10.1016/j.optom.2021.10.003. Epub 2021 Dec 20.
To corroborate whether vessels on the surface of the optic nerve head can provide protection against the loss of underlying axons in subjects with manifest glaucoma.
In this pilot study, thirty-six glaucomatous eyes with a perimetric defect in the Bjerrum area were included. The retinal nerve fiber layer (RNFL) thickness was measured in each of the sectors of the clock-hour map obtained by Cirrus HD-OCT considering the presence or absence of blood vessels. These sectors were related with their corresponding areas of the retina examined in the visual field using a mathematical model of the retina introduced by Jansonius, in order to determine the values of threshold sensitivity in those areas in the presence or absence of vessels.
We corroborated the protective role of the blood vessel for peripapillary RNFL thickness of clock-hour 12 despite obtaining a p-value (p = 0.023; w = 228.5) close to the acceptance zone (p ≥ 0.05). The mean ± standard deviation with vessel and without vessel were 70.95 ± 24.35 and 88.46 ± 23.96, respectively. No differences were found between the mean values of threshold sensitivity to the presence or absence of blood vessels in each of the sectors considered.
Our findings do not allow us to affirm that there is an association between the presence of a vessel and protection against glaucomatous damage in subjects with an advanced manifestation of the disease. In the future, more extensive studies are needed to study this relationship in subjects with early glaucoma.
证实青光眼患者视神经乳头表面的血管是否能保护其下方的轴突免于丢失。
在这项初步研究中，纳入了36只在 Bjerrum 区有视野缺损的青光眼患眼。使用 Cirrus HD-OCT 获得钟点图，根据有无血管测量视网膜神经纤维层（RNFL）在每个扇区的厚度。利用 Jansonius 提出的视网膜数学模型，将这些扇区与其在视野中检查的视网膜相应区域相关联，以确定这些区域在有或无血管情况下的阈值敏感度值。
尽管获得的 p 值（p = 0.023；w = 228.5）接近接受区间（p≥0.05），但我们证实了血管对钟点12处视乳头周围 RNFL 厚度的保护作用。有血管和无血管情况下的平均值±标准差分别为70.95±24.35和88.46±23.96。在所考虑的每个扇区中，有无血管时的阈值敏感度平均值之间未发现差异。
我们的研究结果不允许我们肯定在疾病晚期表现的患者中血管的存在与预防青光眼性损伤之间存在关联。未来，需要更广泛的研究来研究早期青光眼患者中的这种关系。
