Johnson Luke R, Ledoux Joseph E, Doyère Valérie
Department of Psychiatry and Program in Neuroscience, USU Bethesda, MD, USA.
Front Neurosci. 2009 Sep 15;3(2):198-205. doi: 10.3389/neuro.01.027.2009. eCollection 2009 Sep.
The study of memory in most behavioral paradigms, including emotional memory paradigms, has focused on the feed forward components that underlie Hebb's first postulate, associative synaptic plasticity. Hebb's second postulate argues that activated ensembles of neurons reverberate in order to provide temporal coordination of different neural signals, and thereby facilitate coincidence detection. Recent evidence from our groups has suggested that the lateral amygdala (LA) contains recurrent microcircuits and that these may reverberate. Additionally this reverberant activity is precisely timed with latencies that would facilitate coincidence detection between cortical and sub cortical afferents to the LA. Thus, recent data at the microcircuit level in the amygdala provide some physiological evidence in support of the second Hebbian postulate.
在大多数行为范式中，包括情绪记忆范式，对记忆的研究都集中在构成赫布第一假设基础的前馈成分上，即联想性突触可塑性。赫布的第二假设认为，被激活的神经元群体会产生回响，以便为不同的神经信号提供时间协调，从而促进同时性检测。我们团队最近的证据表明，外侧杏仁核（LA）包含循环微回路，并且这些微回路可能会产生回响。此外，这种回响活动的时间精确，其潜伏期有利于LA的皮质和皮质下传入神经之间的同时性检测。因此，杏仁核微回路水平的最新数据为赫布第二假设提供了一些生理学证据。
