Asuquo M E, Ikpeme I A, Bassey E E, Ebughe G
Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria.
Eplasty. 2009 Nov 16;9:e53.
In North America and Europe, 80% of invasive skin cancers are basal cell carcinoma while 20% are squamous cell carcinoma (SCC). In contrast, African studies reveal a preponderance of SCC. Risk factors are grouped into solar and nonsolar. Oculocutaneous albinism (OCA) is a known risk factor for skin cancer in Africans. Their contributions vary with race and geographic region. This study sought to evaluate the pattern, risk factors, and outcome of management of this lesion in our setting.
All the patients with histologic diagnosis of SCC between January 2006 and December 2007 were prospectively studied as part of the wider study of skin cancers.
The 19 patients (12 males and 7 females) whose ages ranged between 16 and 70 years (mean = 46.2 years) accounted for 51.4% of skin malignancies. Marjolin's ulcers were recorded in 12 patients (63.2%) while 7 patients (36.8%) were non-Marjolin's including 2 OCA patients. The limb was the commonest site involved (57.9%). The outcomes were poor in some cases because of late presentation after topical treatment.
Chronic ulcers, inflammation, and albinism were identified predisposing factors. Public health education on prevention, early presentation, and surgical evaluation of chronic ulcers would improve outcome.
在北美和欧洲，80%的侵袭性皮肤癌为基底细胞癌，而20%为鳞状细胞癌（SCC）。相比之下，非洲的研究显示SCC更为常见。危险因素分为日光性和非日光性。眼皮肤白化病（OCA）是非洲人皮肤癌的已知危险因素。它们的作用因种族和地理区域而异。本研究旨在评估我们所在地区该病变的发病模式、危险因素及治疗结果。
作为更广泛的皮肤癌研究的一部分，对2006年1月至2007年12月间所有经组织学诊断为SCC的患者进行前瞻性研究。
19例患者（12例男性和7例女性），年龄在16至70岁之间（平均46.2岁），占皮肤恶性肿瘤的51.4%。12例患者（63.2%）有马乔林溃疡，7例患者（36.8%）为非马乔林溃疡，其中包括2例OCA患者。四肢是最常受累的部位（57.9%）。由于局部治疗后就诊较晚，部分病例的治疗结果较差。
慢性溃疡、炎症和白化病是确定的易感因素。开展关于慢性溃疡预防、早期就诊及手术评估的公共卫生教育将改善治疗结果。
