Icaza Gloria, Núñez Loreto, Marrugat Jaume, Mujica Verónica, Escobar M Cristina, Jiménez Ana Luisa, Pérez Paulina, Palomo Iván
Instituto de Matemática y Física, Universidad de Talca, Talca, Chile.
Rev Med Chil. 2009 Oct;137(10):1273-82.
Cardiovascular disease is the leading cause of morbidity and mortality in Chile and worldwide. Framingham functions were developed to calculate overall coronary heart disease risk. However these functions overestimate the risk in some countries like Chile.
To develop Chilean risk tables to assess the overall 10-year risk of coronary heart disease.
The Framingham function was adapted for a population aged 35 to 74 years, based on an estimate of Chilean incidence of coronary heart disease and the prevalence of coronary heart disease risk factors such as age, sex, total cholesterol, high-density lipoprotein cholesterol, blood pressure, diabetes and smoking.
The 10-year incidence of coronary heart disease in Chile (2.7% in men, 1.096 in women) was lower than the incidence in the United States (10.096/3.896) and Spain (4.996/2.296), but higher than China (1.196/0.496). Framingham tables have more than 50% of cells in the risk category of 10% or greater. In contrast, Chilean tables have less than 10% of cells in the same risk category.
Adapted tables use local information to calculate overall coronary heart disease risk. A validation study should be conducted to assess their predictive power.
心血管疾病是智利乃至全球发病和死亡的主要原因。弗明汉函数用于计算冠心病总体风险。然而，这些函数在智利等一些国家高估了风险。
制定智利风险表以评估冠心病10年总体风险。
基于智利冠心病发病率以及年龄、性别、总胆固醇、高密度脂蛋白胆固醇、血压、糖尿病和吸烟等冠心病危险因素的患病率，对35至74岁人群调整弗明汉函数。
智利冠心病10年发病率（男性为2.7%，女性为1.096%）低于美国（10.096%/3.896%）和西班牙（4.996%/2.296%），但高于中国（1.196%/0.496%）。弗明汉表中10%及以上风险类别的单元格超过50%。相比之下，智利表中同一风险类别的单元格不到10%。
调整后的表格利用当地信息计算冠心病总体风险。应进行验证研究以评估其预测能力。
