Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Genetics and Molecular Biology, Netanya, Israel.
Int J Sports Med. 2009 Dec;30(12):888-91. doi: 10.1055/s-0029-1238291.
Functional R577X (rs.1815739) and ID (rs.5186) polymorphisms in the alpha-actinin-3 ( ACTN3) and the angiotensin converting enzyme (ACE) genes, respectively, have been associated with sprint performance. The aim of this study was to determine their effect on sprint performance among 81 Israeli sprinters and 240 healthy controls. Results revealed that the ACE II genotype+ ACTN3 R allele (P=0.003 for sprinters vs. controls), and the ACTN3 RR genotype +ACE I allele (P=0.001 for sprinters vs. controls) might be the genotype for sprinters. In the whole cohort the probability of ACTN3 RR genotype+ ACE I allele being a sprinter (odds ratio 2.67, 95% confidence interval 1.45-4.93) and of ACE II genotype+ ACTN3 R allele being a sprinter (odds ratio 3.57, 95% confidence interval 1.78-7.15) was significantly higher than that in the controls. In conclusion, the above data suggest that ACE ID/ ACTN3 R577X genotype combination is associated with sprint ability. However, ACE ID/ ACTN3 R577X genotype combination is not related to the level of performance.
功能性 R577X（rs.1815739）和 ID（rs.5186）多态性分别位于α-辅肌动蛋白-3（ACTN3）和血管紧张素转换酶（ACE）基因中，与短跑表现有关。本研究旨在确定它们对 81 名以色列短跑运动员和 240 名健康对照者短跑表现的影响。结果表明，ACE II 基因型+ACTN3 R 等位基因（短跑运动员与对照组相比，P=0.003）和 ACTN3 RR 基因型+ACE I 等位基因（短跑运动员与对照组相比，P=0.001）可能是短跑运动员的基因型。在整个队列中，ACTN3 RR 基因型+ACE I 等位基因是短跑运动员的概率（优势比 2.67，95%置信区间 1.45-4.93）和 ACE II 基因型+ACTN3 R 等位基因是短跑运动员的概率（优势比 3.57，95%置信区间 1.78-7.15）显著高于对照组。总之，上述数据表明 ACE ID/ACTN3 R577X 基因型组合与短跑能力有关。然而，ACE ID/ACTN3 R577X 基因型组合与运动水平无关。
