L-687,781，β-1,3-D-葡聚糖合成抑制剂的papulacandin家族新成员。I. 发酵、分离及生物活性。
L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity.
作者信息
VanMiddlesworth F, Omstead M N, Schmatz D, Bartizal K, Fromtling R, Bills G, Nollstadt K, Honeycutt S, Zweerink M, Garrity G
机构信息
Merck, Sharp & Dohme Research Laboratories, Rahway, N.J. 07065.
出版信息
J Antibiot (Tokyo). 1991 Jan;44(1):45-51. doi: 10.7164/antibiotics.44.45.
PMID:2001985
Abstract
A new beta-1,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.
摘要
一种新的β-1,3-D-葡聚糖合成抑制剂L-687,781是通过培养简单网粘菌ATCC 20960产生的。L-687,781在体外表现出强大的抗真菌活性，并且在大鼠模型中具有抗肺孢子菌活性。
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