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Usefulness of RAS inhibition depends on baseline albuminuria.

作者信息

Ito Sadayoshi

出版信息

Nat Rev Nephrol. 2010 Jan;6(1):10-1. doi: 10.1038/nrneph.2009.203.

DOI:10.1038/nrneph.2009.203
PMID:20023682
Abstract
摘要

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Usefulness of RAS inhibition depends on baseline albuminuria.
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ONTARGET: How much RAS inhibition is enough?
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J Hypertens. 2017 Jul;35(7):1442-1456. doi: 10.1097/HJH.0000000000001325.
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Telmisartan, its potential therapeutic implications in cardiometabolic disorders.替米沙坦及其在心脏代谢紊乱中的潜在治疗意义。
Recent Pat Cardiovasc Drug Discov. 2006 Jan;1(1):79-83. doi: 10.2174/157489006775244281.
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Addition of aliskiren to Angiotensin receptor blocker improves ambulatory blood pressure profile and cardiorenal function better than addition of benazepril in chronic kidney disease.在慢性肾脏病中,与加用贝那普利相比,阿利吉仑联合血管紧张素受体阻滞剂可更好地改善动态血压谱和心肾功能。
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3

本文引用的文献

1
Effect of telmisartan on renal outcomes: a randomized trial.替米沙坦对肾脏结局的影响:一项随机试验。
Ann Intern Med. 2009 Jul 7;151(1):1-10, W1-2. doi: 10.7326/0003-4819-151-1-200907070-00122. Epub 2009 May 18.
2
Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk.应变血管假说:白蛋白尿与心脑血管风险关联的一种观点。
Hypertens Res. 2009 Feb;32(2):115-21. doi: 10.1038/hr.2008.27. Epub 2009 Jan 16.
3
Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients: losartan intervention for endpoint reduction in hypertension study.
The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease.
血管紧张素 II 型 1 型受体阻滞剂奥美沙坦可优先改善慢性肾脏病患者的夜间高血压和蛋白尿。
Hypertens Res. 2013 Mar;36(3):262-9. doi: 10.1038/hr.2012.184. Epub 2012 Nov 15.
4
Cardiorenal connection in chronic kidney disease.慢性肾脏病中心肾关联。
Clin Exp Nephrol. 2012 Feb;16(1):8-16. doi: 10.1007/s10157-011-0493-2. Epub 2011 Nov 1.
5
Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome.坎地沙坦对合并代谢综合征的高血压患者心-踝血管指数的血压非依赖性效应
Vasc Health Risk Manag. 2010 Aug 9;6:571-8. doi: 10.2147/vhrm.s11958.
蛋白尿减少可降低高血压患者的心血管事件:氯沙坦干预降低高血压终点研究
Hypertension. 2005 Feb;45(2):198-202. doi: 10.1161/01.HYP.0000154082.72286.2a. Epub 2005 Jan 17.
4
Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy.蛋白尿,2型糖尿病肾病患者心血管保护的治疗靶点。
Circulation. 2004 Aug 24;110(8):921-7. doi: 10.1161/01.CIR.0000139860.33974.28. Epub 2004 Aug 9.
5
Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL.蛋白尿,2型糖尿病肾病患者肾脏保护的一个靶点:来自RENAAL研究的经验教训
Kidney Int. 2004 Jun;65(6):2309-20. doi: 10.1111/j.1523-1755.2004.00653.x.
6
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy.氯沙坦对2型糖尿病肾病患者肾脏和心血管结局的影响。
N Engl J Med. 2001 Sep 20;345(12):861-9. doi: 10.1056/NEJMoa011161.
7
Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data.血管紧张素转换酶抑制剂与非糖尿病肾病的进展。患者水平数据的荟萃分析。
Ann Intern Med. 2001 Jul 17;135(2):73-87. doi: 10.7326/0003-4819-135-2-200107170-00007.
8
Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.雷米普利与氨氯地平对高血压性肾硬化症肾脏结局的影响:一项随机对照试验。
JAMA. 2001 Jun 6;285(21):2719-28. doi: 10.1001/jama.285.21.2719.
9
Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia).雷米普利对蛋白尿性非糖尿病肾病患者肾小球滤过率下降及终末期肾衰竭风险影响的随机安慰剂对照试验。意大利肾脏病流行病学研究组(GISEN组)
Lancet. 1997 Jun 28;349(9069):1857-63.
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The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.血管紧张素转换酶抑制对糖尿病肾病的影响。协作研究组。
N Engl J Med. 1993 Nov 11;329(20):1456-62. doi: 10.1056/NEJM199311113292004.