Tolstrup Janne S, Grønbaek Morten, Nordestgaard Børge G
Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Circ Cardiovasc Genet. 2009 Oct;2(5):507-14. doi: 10.1161/CIRCGENETICS.109.873604. Epub 2009 Aug 22.
The risk of myocardial infarction is lower among light-to-moderate alcohol drinkers compared with abstainers. We tested associations between alcohol intake and risk of myocardial infarction and risk factors and whether these associations are modified by variations in alcohol dehydrogenases.
We used information on 9584 men and women from the Danish general population in the Copenhagen City Heart Study. During follow-up, from 1991 to 2007, 663 incident cases of myocardial infarction occurred. We observed that increasing alcohol intake was associated with decreasing risk of myocardial infarction, decreasing low-density lipoprotein cholesterol and fibrinogen, increasing diastolic and systolic blood pressure and high-density lipoprotein cholesterol, and with U-shaped nonfasting triglycerides. In contrast, ADH1B and ADH1C genotypes were not associated with risk of myocardial infarction or with any of the cardiovascular biochemical risk factors, and there was no indication that associations between alcohol intake and myocardial infarction and between alcohol intake and risk factors were modified by genotypes.
Increasing alcohol intake is associated with decreasing risk of myocardial infarction, decreasing low-density lipoprotein cholesterol and fibrinogen, increasing diastolic and systolic blood pressure and high-density lipoprotein cholesterol, and U-shaped nonfasting triglycerides. These associations were not modified by ADH1B and ADH1C are genotypes.
与戒酒者相比，轻度至中度饮酒者发生心肌梗死的风险较低。我们测试了酒精摄入量与心肌梗死风险及危险因素之间的关联，以及这些关联是否会因酒精脱氢酶的变异而改变。
我们利用了哥本哈根城市心脏研究中来自丹麦普通人群的9584名男性和女性的信息。在1991年至2007年的随访期间，发生了663例心肌梗死病例。我们观察到，酒精摄入量增加与心肌梗死风险降低、低密度脂蛋白胆固醇和纤维蛋白原降低、舒张压和收缩压及高密度脂蛋白胆固醇升高以及非空腹甘油三酯呈U形相关。相比之下，ADH1B和ADH1C基因型与心肌梗死风险或任何心血管生化危险因素均无关联，且没有迹象表明酒精摄入量与心肌梗死之间以及酒精摄入量与危险因素之间的关联会因基因型而改变。
酒精摄入量增加与心肌梗死风险降低、低密度脂蛋白胆固醇和纤维蛋白原降低、舒张压和收缩压及高密度脂蛋白胆固醇升高以及非空腹甘油三酯呈U形相关。这些关联不会因ADH1B和ADH1C基因型而改变。
