Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden.
Food Chem Toxicol. 2010 Mar;48(3):820-4. doi: 10.1016/j.fct.2009.12.014. Epub 2009 Dec 23.
Our purpose was to investigate whether alcohol (ethanol) consumption could have an influence on the metabolism of acrylamide to glycidamide in humans exposed to acrylamide through food. We studied a subsample from a population-based case-control study of prostate cancer in Sweden (CAPS). Questionnaire data for alcohol intake estimates was compared to the ratio of hemoglobin-adduct levels for acrylamide and glycidamide, used as a measure of individual differences in metabolism. Data from 161 non-smoking men were processed with regard to the influence of alcohol on the metabolism of acrylamide to glycidamide. A negative, linear trend of glycidamide-adduct to acrylamide-adduct-level ratios with increasing alcohol intake was observed and the strongest association (p-value for trend=0.02) was obtained in the group of men with the lowest adduct levels (47 pmol/g globin) when alcohol intake was stratified by acrylamide-adduct levels. The observed trend is likely due to a competitive effect between ethanol and acrylamide as both are substrates for cytochrome P450 2E1. Our results, strongly indicating that ethanol influence metabolism of acrylamide to glycidamide, partly explain earlier observations of only low to moderate associations between questionnaire data on dietary acrylamide intake and hemoglobin-adduct levels.
我们的目的是研究在通过食物接触丙烯酰胺的人群中，饮酒（乙醇）是否会影响丙烯酰胺向丙烯醛的代谢。我们研究了瑞典前列腺癌基于人群的病例对照研究（CAPS）的一个亚样本。酒精摄入量估计的问卷调查数据与血红蛋白加合物水平的丙烯酰胺和丙烯醛的比值进行了比较，该比值用作个体代谢差异的衡量标准。对 161 名不吸烟男性的数据进行了处理，以研究酒精对丙烯酰胺向丙烯醛代谢的影响。观察到随着酒精摄入量的增加，丙烯醛加合物与丙烯酰胺加合物水平比值呈负线性趋势，并且在丙烯酰胺加合物水平最低的男性组中（47 pmol/g 球蛋白），相关性最强（趋势检验的 p 值=0.02）。当按丙烯酰胺加合物水平对酒精摄入量进行分层时，观察到的趋势可能是由于乙醇和丙烯酰胺之间的竞争效应，因为它们都是细胞色素 P450 2E1 的底物。我们的结果强烈表明，乙醇会影响丙烯酰胺向丙烯醛的代谢，这部分解释了先前仅观察到饮食中丙烯酰胺摄入量和血红蛋白加合物水平之间存在低至中度关联的原因。
