Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, USA.
Oral Oncol. 2010 Feb;46(2):77-81. doi: 10.1016/j.oraloncology.2009.11.008. Epub 2009 Dec 28.
Taste dysfunction in cancer patients impacts quality of life and impairs oral intake, which may have broader implications consisting of weight loss and nutritional compromise. These consequences may in turn affect broad symptom clusters including tissue healing, energy levels and mood. Patient evaluation and management should include a complete patient history and examination, and may require special tests. Patient-reported outcomes together with taste and smell testing are often necessary for diagnosis and management of taste disorders. Understanding, prevention and management of taste disorders in cancer patients requires continuing study. Current practice and recommendations are based on limited evidence. Due to its potentially significant impact on quality of life during and following cytotoxic therapy, and considering the increase in cancer survivorship, further research on this topic is imperative.
癌症患者的味觉功能障碍会影响生活质量，降低口腔摄入，这可能会导致更广泛的后果，包括体重减轻和营养不足。这些后果反过来可能会影响广泛的症状群，包括组织愈合、能量水平和情绪。患者的评估和管理应包括完整的病史和体检，可能需要特殊检查。患者报告的结果以及味觉和嗅觉测试通常是诊断和管理味觉障碍所必需的。了解、预防和管理癌症患者的味觉障碍需要持续研究。目前的实践和建议基于有限的证据。由于味觉障碍在细胞毒性治疗期间和之后对生活质量可能有重大影响，并且考虑到癌症存活率的增加，因此必须对这一主题进行进一步研究。
