Radiation and Nuclear Safety Authority (STUK), Research and Environmental Surveillance, Helsinki, Finland.
Cancer Causes Control. 2010 Apr;21(4):587-95. doi: 10.1007/s10552-009-9488-7. Epub 2009 Dec 27.
The objective of this paper was to study cancer incidence, especially leukemia in children (<15 years), in the vicinity of Finnish nuclear power plants (NPPs). We used three different approaches: ecological analysis at municipality level, residential cohorts defined from census data, and case-control analysis with individual residential histories. The standardized incidence ratio of childhood leukemia for the seven municipalities in the vicinity of NPPs was 1.0 (95% CI 0.6, 1.6) compared to the rest of Finland. The two cohorts defined by censuses of 1980 and 1990 gave rate ratios of 1.0 (95% CI 0.3, 2.6) and 0.9 (95% CI 0.2, 2.7), respectively, for childhood leukemia in the population residing within 15 km from the NPPs compared to the 15-50 km zone. The case-control analysis with 16 cases of childhood leukemia and 64 matched population-based controls gave an odds ratio for average distance between residence and NPP in the closest 5-9.9 km zone of 0.7 (95% CI 0.1, 10.4) compared to > or =30 km zone. Our results do not indicate an increase in childhood leukemia and other cancers in the vicinity of Finnish NPPs though the small sample size limits the strength of conclusions. The conclusion was the same for adults.
本文旨在研究芬兰核电站（NPP）附近儿童（<15 岁）癌症的发病情况，尤其是白血病。我们采用了三种不同的方法：市级生态分析、根据人口普查数据定义的居住队列和基于个体居住史的病例对照分析。与芬兰其他地区相比，NPP 附近七个市的儿童白血病标准化发病比为 1.0（95%CI 0.6，1.6）。根据 1980 年和 1990 年的两次人口普查定义的两个队列，居住在距离 NPP 15 公里以内的人群中儿童白血病的比率分别为 1.0（95%CI 0.3，2.6）和 0.9（95%CI 0.2，2.7），而居住在距离 NPP 15-50 公里范围内的人群中儿童白血病的比率分别为 0.3（95%CI 0.1，2.6）和 0.2（95%CI 0.1，2.7）。基于 16 例儿童白血病病例和 64 例匹配的基于人群的对照，对距离最近的 5-9.9 公里区域的住所和 NPP 之间的平均距离进行病例对照分析，发现比值比为 0.7（95%CI 0.1，10.4），而对于距离大于等于 30 公里区域的比值比为 1.0（95%CI 0.1，10.4）。尽管样本量较小限制了结论的强度，但我们的研究结果并未表明芬兰 NPP 附近儿童白血病和其他癌症的发病率增加。结论同样适用于成年人。
