Post-graduate Program, Health and Behaviour, Catholic University of Pelotas, Rua Porto Alegre 492, 96090-520 Pelotas, RS, Brazil.
Support Care Cancer. 2010 Feb;19(2):187-92. doi: 10.1007/s00520-009-0798-9. Epub 2009 Dec 29.
Phase angle (PA), determined by bioelectrical impedance analysis (BIA), has been considered as a prognostic factor in several clinical conditions. The purpose of this study is to investigate PA, after adjusting for sex and age (standardized phase angle; SPA) as a prognostic factor for survival in cancer patients.
A prospective study was conducted in 195 patients before the first chemotherapy course. BIA was performed in all patients and SPA was calculated. The Kaplan-Meier method was used to calculate survival. The Cox regression method was used to evaluate the independent prognostic effect of PA after adjustment for other variables.
Patients with SPA < -1.65 had a smaller survival rate than those with SPA ≥ -1.65 (p < 0.001). Using Cox regression, the mortality rate was higher in patients with SPA < -1.65 (RR 3.12 CI: 2.03-4.79; p < 0.001). After multivariate analysis, patients with PA < -1.65 still presented a higher mortality rate (RR 2.35 CI: 1.41-3.90; p = 0.001).
The present study demonstrates that PA, used as SPA, is an independent prognostic indicator in this group of cancer patients receiving chemotherapy treatment even after adjustment for other prognostic variables.
相位角（PA）通过生物电阻抗分析（BIA）确定，已被认为是几种临床情况下的预后因素。本研究旨在探讨 PA 在调整性别和年龄后（标准化相位角；SPA）作为癌症患者生存的预后因素。
对 195 例首次化疗前的患者进行前瞻性研究。所有患者均进行 BIA 并计算 SPA。采用 Kaplan-Meier 法计算生存。采用 Cox 回归方法评估 PA 在调整其他变量后的独立预后作用。
SPA< -1.65 的患者生存率低于 SPA ≥ -1.65 的患者（p<0.001）。Cox 回归分析显示，SPA< -1.65 的患者死亡率更高（RR 3.12 CI：2.03-4.79；p<0.001）。多因素分析后，SPA< -1.65 的患者死亡率仍较高（RR 2.35 CI：1.41-3.90；p=0.001）。
本研究表明，PA 作为 SPA，即使在调整其他预后变量后，也是接受化疗的癌症患者的独立预后指标。
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