Detmar M, Pauli G, Anagnostopoulos I, Wunderlich U, Herbst H, Garbe C, Stein H, Orfanos C E
Department of Dermatology, University Medical Center Steglitz, Free University of Berlin, Germany.
Br J Dermatol. 1991 Feb;124(2):198-202. doi: 10.1111/j.1365-2133.1991.tb00434.x.
A 72-year-old male patient from north-eastern Iran developed the typical clinical and histopathological features of mycosis fungoides with lymphadenopathy, but without any other systemic involvement. Human T-cell lymphotropic virus (HTLV-I) antibodies were detected in the patient's serum by two different ELISAs and by Western blot using purified viral particles from MT-2 culture supernatants. Cultured peripheral blood lymphocytes were positive for labelling with anti-HTLV-I serum. Southern blot hybridization of DNA extracted from a skin tumour and from an involved lymph node revealed integrated proviral DNA with identical restriction patterns. This case supports a relationship between mycosis fungoides and HTLV-I and may indicate a new region of endemic HTLV-I infection.
一名来自伊朗东北部的72岁男性患者出现了蕈样肉芽肿伴淋巴结病的典型临床和组织病理学特征，但无任何其他全身受累情况。通过两种不同的酶联免疫吸附测定法以及使用来自MT-2培养上清液的纯化病毒颗粒进行的蛋白质印迹法，在患者血清中检测到了人类嗜T细胞病毒（HTLV-I）抗体。培养的外周血淋巴细胞用抗HTLV-I血清标记呈阳性。从皮肤肿瘤和受累淋巴结提取的DNA进行的Southern印迹杂交显示，整合的前病毒DNA具有相同的限制性图谱。该病例支持蕈样肉芽肿与HTLV-I之间的关联，并可能表明存在HTLV-I感染的新流行区域。
