Barua Chandana C, Talukdar Archana, Begum Shameem A, Lahon Lalit C, Sarma Dilip K, Pathak Debesh C, Borah Probodh
Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781 022, India.
Indian J Exp Biol. 2010 Aug;48(8):817-21.
Antinociceptive activity of methanolic extract of leaves of A. aspera was studied by peripheral/non-narcotic model of nociception like acetic acid induced writhing syndrome test and central/narcotic models like hot plate and tail flick tests. The methanolic extract of the plant, administered orally (@ 300, 600 and 900 mg/kg, body weight) and the standard drug (piroxicam; 10 mg/kg body weight, po) produced significant analgesic activity in acetic acid induced writhing syndrome as compared to the vehicle treated control group. In the hot plate analgesic test, in A. aspera at the above doses and the standard drug treated group (morphine sulphate @ 1.5 mg/kg, ip), the duration of reaction time (sec) increased dose dependently and significantly compared to the control group. In the tail flick test, the plant extract produced dose dependant increase in reaction time which was significantly higher in the test and standard group compared to the control group. The plant possesses significant antinociceptive property as evidenced in all the animal models of nociception. It might possibly exert its effect through diverse mechanism that may involve both central and peripheral pathways. The preliminary phytochemical investigation revealed the presence of steroids, alkaloids and triterpene in the methanolic extract of leaves of A. aspera which may be responsible for its antinociceptive activity.
通过外周/非麻醉性伤害感受模型（如醋酸诱导扭体综合征试验）和中枢/麻醉性模型（如热板试验和甩尾试验）研究了糙叶榕叶甲醇提取物的抗伤害感受活性。与赋形剂处理的对照组相比，该植物的甲醇提取物经口服给药（@300、600和900mg/kg体重）和标准药物（吡罗昔康；10mg/kg体重，口服）在醋酸诱导的扭体综合征中产生了显著的镇痛活性。在热板镇痛试验中，糙叶榕在上述剂量下以及标准药物治疗组（硫酸吗啡@1.5mg/kg，腹腔注射）与对照组相比，反应时间（秒）的持续时间呈剂量依赖性显著增加。在甩尾试验中，植物提取物使反应时间呈剂量依赖性增加，试验组和标准组的反应时间显著高于对照组。在所有伤害感受动物模型中均证明该植物具有显著的抗伤害感受特性。它可能通过多种机制发挥作用，这些机制可能涉及中枢和外周途径。初步植物化学研究表明，糙叶榕叶甲醇提取物中存在甾体、生物碱和三萜，这可能是其抗伤害感受活性的原因。
