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在德国波恩所研究的所有年龄组中，针对人偏肺病毒的中和能力血清阳性率很高。

High seroprevalence of neutralizing capacity against human metapneumovirus in all age groups studied in Bonn, Germany.

作者信息

Lüsebrink Jessica, Wiese Christoph, Thiel Anne, Tillmann Ramona-Liza, Ditt Vanessa, Müller Andreas, Schildgen Oliver, Schildgen Verena

机构信息

Institute for Virology, University of Bonn Medical Centre, Bonn, Germany.

出版信息

Clin Vaccine Immunol. 2010 Mar;17(3):481-4. doi: 10.1128/CVI.00398-09. Epub 2009 Dec 30.

DOI:10.1128/CVI.00398-09
PMID:20042516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2837972/
Abstract

Human metapneumovirus (hMPV) infections occur frequently despite high rates of perpetual seroprevalence for all age groups. Analyses of approximately 2,000 archived, randomly selected serum samples demonstrated that neutralizing capacities remain high, with a minor decrease for individuals over 69 years of age, leading to the hypothesis that reinfections occur because humoral immune responses play minor roles in the clearance of hMPV infections.

摘要

尽管所有年龄组的永久血清阳性率很高，但人偏肺病毒（hMPV）感染仍频繁发生。对大约2000份随机选取的存档血清样本进行分析表明，中和能力仍然很高，69岁以上个体的中和能力略有下降，这导致了一种假设，即再次感染会发生是因为体液免疫反应在清除hMPV感染中起的作用较小。

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1
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J Virol Methods. 2010 Jan;163(1):74-81. doi: 10.1016/j.jviromet.2009.08.024. Epub 2009 Sep 30.
2
Age-associated aggravation of clinical disease after primary metapneumovirus infection of BALB/c mice.BALB/c小鼠初次感染人偏肺病毒后临床疾病的年龄相关性加重。
J Virol. 2009 Apr;83(7):3323-32. doi: 10.1128/JVI.02198-08. Epub 2009 Jan 14.
3
Diagnosis and epidemiological studies of human metapneumovirus using real-time PCR.使用实时荧光定量聚合酶链反应对人偏肺病毒进行诊断及流行病学研究
J Clin Virol. 2007 Nov;40(3):186-92. doi: 10.1016/j.jcv.2007.08.004. Epub 2007 Sep 17.
4
Human metapneumovirus infection in a hematopoietic transplant recipient.一名造血干细胞移植受者的人偏肺病毒感染
Bone Marrow Transplant. 2007 Oct;40(7):699-700. doi: 10.1038/sj.bmt.1705781. Epub 2007 Jul 30.
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