Department of Internal Medicine I, University of Regensburg, D-93042 Regensburg, Germany.
Int J Oncol. 2010 Feb;36(2):435-41.
Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concentration of 25 microM induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed proliferation and migration, as well as TNF induced NF-kappaB activity and interleukin-8 expression in both cell lines at even lower concentrations. In contrast, xanthohumol concentrations up to 100 microM did not affect viability of primary human hepatocytes in vitro. In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells.
黄腐酚是啤酒花中主要的类异戊二烯查尔酮，具有显著的抗癌作用，但有关其对肝癌（HCC）细胞的影响以及对非肿瘤性肝细胞的潜在不良作用的信息有限。在这里，我们发现 25μM 的黄腐酚可诱导两种 HCC 细胞系（HepG2 和 Huh7）凋亡。此外，黄腐酚在更低的浓度下还抑制了增殖和迁移，以及 TNF 诱导的 NF-κB 活性和两种细胞系中白细胞介素-8 的表达。相比之下，高达 100μM 的黄腐酚浓度在体外不影响原代人肝细胞的活力。总之，我们的数据表明，黄腐酚可以改善已知促进 HCC 进展的不同促肿瘤发生机制，表明其作为一种有前途的治疗剂具有选择性地影响癌细胞的潜力。
