Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144 411, India.
Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
Int J Mol Sci. 2021 Apr 25;22(9):4478. doi: 10.3390/ijms22094478.
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure-activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.
黄腐酚（XH）是一种重要的类异戊二烯类黄酮，存在于 （啤酒花植物）的花序中。XH 是啤酒中的一种重要成分，由于其多种药用应用而被认为是一种重要的生物活性物质，包括抗炎、抗菌、抗氧化、免疫调节、抗病毒、抗真菌、抗原毒性、抗血管生成和抗疟作用以及对各种类型癌细胞的强烈抗癌活性。XH 作为一种广泛的化学预防和抗癌药物，其异构体 8-异戊烯基柚皮素是一种具有强雌激素活性的植物雌激素。本综述重点介绍了 XH 对各种癌症的生物活性及其药代动力学。在本文中，我们首先简要介绍了啤酒花的历史和用途，然后介绍了 XH 的化学和构效关系。最后，我们重点介绍了它对各种癌症的突出作用和作用机制及其在癌症预防和治疗中的可能用途。考虑到关于这个主题的可用评论数量有限，我们的目标是提供对 XH 对不同癌症的抗癌作用的全面和详细的理解。
