Division of Plastic Surgery; University of California at Davis; Sacramento, CA USA.
Organogenesis. 2009 Jul;5(3):138-42. doi: 10.4161/org.5.3.9586.
The main obstacle to achieving favorable outcome of soft-tissue augmentation after autologous fat transplantation is unpredictable long-term results due to the high rate of absorption in the grafted site. At the present time, adipose aspirates can only be used for immediate autologous fat grafting during the same procedure in which liposuction is performed; therefore adipose aspirates obtained from the procedure are usually discarded. it has been a strong desire of both surgeons and patients to be able to preserve the adipose aspirates, if an optimal technique were available, for potential future applications. For the last several years, cryopreservation of adipose tissue has been studied extensively in the author's laboratory. Several findings from this exciting translational research will lead to develop a reliable method for long-term preservation of adipose tissue in the future. in addition, successful long-term preservation of adipose tissue may open a new era in adipose tissue related tissue regeneration.
自体脂肪移植后软组织填充效果良好的主要障碍是移植物部位吸收率高，导致长期效果不可预测。目前，脂肪抽吸物只能在吸脂术的同时立即用于自体脂肪移植；因此，从手术中获得的脂肪抽吸物通常会被丢弃。如果有最佳技术，能够保存脂肪抽吸物，这是外科医生和患者的强烈愿望，以备将来潜在应用。在过去的几年中，作者实验室已经对脂肪组织的冷冻保存进行了广泛研究。这项令人兴奋的转化研究的一些发现将为未来开发可靠的长期保存脂肪组织的方法奠定基础。此外，成功的长期脂肪组织保存可能会开启脂肪组织相关组织再生的新时代。
