Aakeröy Christer B, Schultheiss Nate, Rajbanshi Arbin, Desper John, Moore Curtis
Contribution from the Department of Chemistry, Kansas State University, 111 Willard Hall, Manhattan, Kansas, 66506.
Cryst Growth Des. 2009;9(1):432-441. doi: 10.1021/cg8006712.
A family of supramolecular reagents containing two different binding sites, pyridine and amino-pyrimidine, were allowed to react with iodo- or bromo-substituted benzoic acids in order to assemble individual molecules into larger architectures with precise intermolecular interactions, using a combination of hydrogen- and halogen-bonds. The hydrogen-bond based amino-pyrimidine/carboxylic acid or amino-pyrimidinium/carboxylate synthons are responsible for the assembly of the primary structural motif in every case (7/7 times, 100% supramolecular yield), while Icdots, three dots, centeredN, Brcdots, three dots, centeredN, and Icdots, three dots, centeredO, halogen bonds play a structural supporting role by organizing these supermolecules into extended 1-D and 2-D architectures (5/7 times, 71% supramolecular yield). These results illustrate how two different non-covalent interactions can be employed side-by-side in the reliable construction of extended molecular solid-state networks with predictable connectivity and dimensionality.
让一族含有两个不同结合位点（吡啶和氨基嘧啶）的超分子试剂与碘代或溴代取代苯甲酸反应，以便利用氢键和卤键的组合，通过精确的分子间相互作用将单个分子组装成更大的结构。基于氢键的氨基嘧啶/羧酸或氨基嘧啶鎓/羧酸盐合成子在每种情况下都负责一级结构基序的组装（7/7次，超分子产率100%），而···I···N居中、···Br···N居中以及···I···O居中的卤键通过将这些超分子组织成扩展的一维和二维结构来发挥结构支撑作用（5/7次，超分子产率71%）。这些结果说明了如何在可靠构建具有可预测连接性和维度的扩展分子固态网络中并行使用两种不同的非共价相互作用。
