Gorpelioglu Canan, Erdal Emel, Ardicoglu Yasemin, Adam Bahattin, Sarifakioglu Evren
Department of Dermatology, Fatih University Faculty of Medicine, Ayranci, Ankara, Turkey.
Indian J Dermatol. 2009;54(1):20-2. doi: 10.4103/0019-5154.48980.
To investigate the relationship between serum leptin, atherogenic lipid and glucose levels in patients with skin tags and healthy controls.
A total of 58 patients, with at least three skin tags, aged 24 to 85 years, and 31 healthy controls aged 30 to 70 years, were examined in the present study. The subjects in all the groups were selected with statistically similar Body Mass Index (BMI). Fasting concentrations of plasma glucose, serum lipids including triglyceride, total cholesterol, and high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL), HbA1c, and leptin were measured by enzyme-linked immunosorbent assay (ELISA). In addition, serum LDL level was calculated using Friedewald's formula.
There was no significant difference in age, sex, BMI, HbA1c, triglyceride, HDL and leptin levels between the groups. Skin tags group showed significantly higher levels of total cholesterol and LDL, when compared with the healthy controls groups (P < 0.01). In addition, regression analysis showed that leptin level was positively correlated to serum triglyceride level (r = 0.265, P = 0.044).
Total cholesterol and LDL serum levels should be controlled in patients with skin tags. On the other hand, glucose, leptin and HbA1c serum levels may not be as important as is being considered in recent times.
研究患有皮赘的患者与健康对照者血清瘦素、致动脉粥样硬化脂质和血糖水平之间的关系。
本研究共检查了58例年龄在24至85岁、至少有三个皮赘的患者，以及31例年龄在30至70岁的健康对照者。所有组别的受试者均以具有统计学相似性的体重指数（BMI）进行选择。采用酶联免疫吸附测定法（ELISA）测量空腹血浆葡萄糖、血清脂质（包括甘油三酯、总胆固醇、高密度脂蛋白胆固醇（HDL）和低密度脂蛋白胆固醇（LDL））、糖化血红蛋白（HbA1c）和瘦素的浓度。此外，血清LDL水平使用Friedewald公式计算。
两组在年龄、性别、BMI、HbA1c、甘油三酯、HDL和瘦素水平方面无显著差异。与健康对照组相比，皮赘组的总胆固醇和LDL水平显著更高（P < 0.01）。此外，回归分析表明瘦素水平与血清甘油三酯水平呈正相关（r = 0.265，P = 0.044）。
皮赘患者应控制血清总胆固醇和LDL水平。另一方面，血清葡萄糖、瘦素和HbA1c水平可能不像近期所认为的那么重要。
