Mehra R K, Winge D R
Department of Medicine, University of Utah, Salt Lake City 84132.
J Cell Biochem. 1991 Jan;45(1):30-40. doi: 10.1002/jcb.240450109.
One stress response in cells is the ability to survive in an environment containing excessive concentrations of metal ions. This paper reviews current knowledge about cellular and molecular mechanisms involved in the response and adaptation of various fungal species to metal stress. Most cells contain a repertoire of mechanisms to maintain metal homeostasis and prevent metal toxicity. Roles played by glutathione, related (gamma-EC)nG peptides, metallothionein-like polypeptides, and sulfide ions are discussed. In response to cellular metal stress, the biosynthesis of some of these molecules are metalloregulated via intracellular metal sensors. The identify of the metal sensors and the role of metal ions in the regulation of biosynthesis of metallothionein and (gamma-EC)nG peptides are subjects of much current attention and are discussed herein.
细胞中的一种应激反应是在含有过量金属离子的环境中存活的能力。本文综述了目前关于各种真菌物种对金属胁迫的反应和适应所涉及的细胞和分子机制的知识。大多数细胞都有一系列维持金属稳态和防止金属毒性的机制。文中讨论了谷胱甘肽、相关的（γ-EC）nG肽、类金属硫蛋白多肽和硫化物离子所起的作用。响应细胞金属胁迫时，这些分子中的一些生物合成通过细胞内金属传感器进行金属调节。金属传感器的身份以及金属离子在金属硫蛋白和（γ-EC）nG肽生物合成调节中的作用是目前备受关注的课题，本文对此进行了讨论。
