Allergy/Immunology Department at Ear, Nose and Throat Associates of North Central Wisconsin, 2801 Westhill Dr., Wausau, WI 54401, USA.
Int J Mol Sci. 2009 Dec 21;10(12):5471-84. doi: 10.3390/ijms10125471.
Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.
大环三萜烯类化合物是由串珠镰刀菌产生的霉菌毒素，与暴露于霉菌污染环境中的个体的不良反应有关。在与霉菌相关的健康问题患者中，评估了细胞和体液免疫反应以及霉菌毒素的存在。患者接受了病史、体格检查、用霉菌提取物进行皮试/穿刺试验、免疫学评估，并对其血清进行了霉菌毒素分析。与对照组相比，T 细胞增殖、大环三萜烯类化合物以及霉菌特异性 IgG 和 IgA 水平没有显著差异；然而，70%的患者对霉菌的皮肤试验呈阳性。因此，可能是 IgE 介导或其他非免疫机制导致了他们的症状。
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