Department of Animal & Food Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Mycopathologia. 2010 Dec;170(6):377-90. doi: 10.1007/s11046-010-9330-5. Epub 2010 Jun 13.
Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell damage can occur from satratoxin H exposure to neurological cells at exposure levels that can be found in water-damaged buildings contaminated with fungal growth. The constant activation of inflammatory and apoptotic pathways at low levels of exposure in human brain capillary endothelial cells, astrocytes, and neural progenitor cells may amplify devastation to neurological tissues and lead to neurological system cell damage from indirect events triggered by the presence of trichothecenes.
暴露于真菌毒素会对人类神经系统细胞造成损伤，这一事实证实了此前备受争议的水损建筑物居住者所面临的公共健康威胁。对于吸入室内环境中的真菌毒素是否会对人类健康产生不良影响，主要的科学组织存在分歧。神经系统的损伤可能是由于室内环境中的曲霉菌毒素所致。本研究表明，satratoxin H 可以对神经系统细胞造成损伤，而这种 satratoxin H 的暴露水平在受真菌生长污染的水损建筑物中是可以检测到的。在人类脑毛细血管内皮细胞、星形胶质细胞和神经祖细胞中，低水平暴露时炎症和细胞凋亡途径的持续激活，可能会放大对神经系统组织的破坏，并导致由曲霉菌引起的间接事件引发的神经系统细胞损伤。
