Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Adv Exp Med Biol. 2009;666:19-31. doi: 10.1007/978-1-4419-1601-3_2.
When bacteria invade the human host, they are directly confronted with a serious threat, the human innate immune system. This chapter describes the challenge that a staphylococci face and recent findings on how this bacterium counteracts the massive attack of this innate immune system. In order to survive within the human host, staphylococci have evolved a wide variety of small, excreted proteins that interfere with subsequent steps of the human innate immune system cascade.
当细菌侵入人体宿主时，它们会直接面临一个严重的威胁，即人体先天免疫系统。本章描述了葡萄球菌面临的挑战，以及最近关于这种细菌如何对抗这种先天免疫系统的大量攻击的发现。为了在人体宿主中生存，葡萄球菌已经进化出了各种各样的小分泌蛋白，这些蛋白会干扰人体先天免疫系统级联反应的后续步骤。
