Faculty of Pharmacy, Department of Radiopharmacy, Hacettepe University, 06100 Ankara, Turkey.
J Biomed Nanotechnol. 2009 Apr;5(2):141-50. doi: 10.1166/jbn.2009.1016.
Currently used imaging modalities such as scintigraphy, computed tomography, magnetic resonance imaging and ultrasonography require the sufficient intensity of a corresponding signal from an area of interest to differentiate this area from the surrounding tissues. Targeting of various reporter moieties directly to the specific organs, tissues or tumors provide the highest dose of drug directly where it is needed. Many different types of nanoparticles are currently being studied for applications in nanomedicine. Among particulate drug carriers, liposomes are one of the most extensively studied and possess the most suitable characteristics for encapsulation of many drugs, genes, and diagnostic (imaging) agents. Among the many potential targets for such nanocarriers, tumors have been most often investigated. This review attempts to summarize the currently available information regarding liposomal nanocarriers for cancer imaging.
目前使用的成像方式，如闪烁扫描、计算机断层扫描、磁共振成像和超声检查，需要有足够强度的目标区域信号，以将该区域与周围组织区分开来。将各种报告分子直接靶向特定的器官、组织或肿瘤，可以将药物直接输送到需要的地方。目前，许多不同类型的纳米颗粒正在被研究用于纳米医学应用。在颗粒药物载体中，脂质体是研究最广泛的一种，并且具有最适合封装许多药物、基因和诊断（成像）试剂的特性。在如此多的潜在纳米载体靶点中，肿瘤是最常被研究的。本综述试图总结目前关于用于癌症成像的脂质体纳米载体的可用信息。
