Torchilin V P
Center for Imaging and Pharmaceutical Research, Massachusetts General Hospital, Charlestown, USA.
Mol Med Today. 1996 Jun;2(6):242-9. doi: 10.1016/1357-4310(96)88805-8.
Medical imaging requires an appropriate intensity of signal from the area of interest in order to differentiate certain structures from surrounding tissues, regardless of the modality used. In the majority of cases, contrast agents specific for each imaging modality are necessary to achieve a sufficiently intense signal. To facilitate the accumulation of contrast in the required zone, various microparticulates have been suggested as carriers for contrast agents. Among these carriers, liposomes-microscopic artificial phospholipid vesicles-draw special attention because of their easily controlled properties and useful pharmacological characteristics. This review will discuss how the advantages of liposomes have been used so far in the rapidly growing field of diagnostic medical imaging.
医学成像需要来自感兴趣区域的适当信号强度，以便将某些结构与周围组织区分开来，无论使用何种成像方式。在大多数情况下，每种成像方式所特有的造影剂对于获得足够强的信号是必要的。为了促进造影剂在所需区域的积聚，人们提出了各种微粒作为造影剂的载体。在这些载体中，脂质体——微观的人工磷脂囊泡——因其易于控制的特性和有用的药理学特性而备受关注。本综述将讨论脂质体的优势在快速发展的诊断医学成像领域中迄今是如何得到应用的。
