Department of Materials Science and Engineering, University of Florida, Gainesville, Florida 32611-6400, USA.
Nano Lett. 2010 Feb 10;10(2):567-72. doi: 10.1021/nl903468p.
Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale biosensors and facilitate the rapid detection of analytes. Here, the possible increase of the signal-to-noise ratio is calculated, and the optimal layout of a system which integrates active transport is determined.
纳米级传感器能够提高信号与噪声比来进行分析物的检测，但却受到传质限制。分子梭由抗体功能化的微管和驱动蛋白运动蛋白组装而成，可以从溶液中选择性地捕获分析物，并将其递送至传感器片。这个两阶段过程可以加速质量传递到纳米级生物传感器，并促进分析物的快速检测。在此，计算了信号与噪声比的可能增加，并确定了集成主动运输的系统的最佳布局。
