海绵 Hyatella sp. 中的倍半萜类化合物

Scalarane sesterterpenes from the sponge Hyatella sp.

机构信息

Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.

出版信息

J Nat Prod. 2011 Apr 25;74(4):847-51. doi: 10.1021/np1006873. Epub 2011 Feb 22.

DOI:10.1021/np1006873

PMID:21341710

Abstract

Five new sesterterpenes (7-11) along with six known compounds (1-6) were isolated from the sponge Hyatella sp., collected off the coast of Soheuksan-do, Korea. Spectroscopic analyses revealed these compounds as scalarane sesterterpenes with oxidized furan moieties (7-10) and a corresponding lactam (11). The compounds exhibited moderate cytotoxicity, antibacterial activity, and weak inhibitory activity against isocitrate lyase.

摘要

从韩国所珍岛海域采集的海绵Hyatella sp. 中分离得到 5 个新的倍半萜（7-11）和 6 个已知化合物（1-6）。光谱分析表明这些化合物为具有氧化呋喃部分（7-10）和相应内酰胺（11）的海鞘烷倍半萜。这些化合物表现出中等的细胞毒性、抗菌活性和对异柠檬酸裂解酶的弱抑制活性。