Department of Epidemiology and Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
Environ Health Perspect. 2010 Jan;118(1):60-6. doi: 10.1289/ehp.0900919.
Organochlorine (OC) pesticides are a group of environmental endocrine disruptors that may be associated with an increased risk for hormone-related cancers including cancers of the breast and prostate. However, epidemiologic evidence is limited and inconsistent.
We used 1999-2004 National Health and Nutrition Examination Survey data to examine associations between serum concentrations of OC pesticides and prostate and breast cancers.
After adjustment for other covariates, serum concentrations of beta-hexachlorocyclohexane (HCH) (p for trend = 0.02), trans-nonachlor (p for trend = 0.002), and dieldrin (p for trend = 0.04) were significantly associated with the risk of prevalent prostate cancer. Adjusted odds ratios for the second and third tertiles of detectable values were 1.46 [95% confidence interval (CI), 0.52-4.13] and 3.36 (95% CI, 1.24-9.10) for beta-HCH; 5.84 (95% CI, 1.06-32.2) and 14.1 (95% CI, 2.55-77.9) for trans-nonachlor; and 1.06 (95% CI, 0.30-3.73) and 2.74 (95% CI, 1.01-7.49) for dieldrin compared with concentrations in the lowest tertile or below the limit of detection. However, there was no positive association between serum concentrations of OC pesticides and breast cancer prevalence.
Although further study is necessary to confirm these findings, these results suggest that OC pesticide exposures may have a significant effect on cancer risk. Efforts to reduce worldwide OC use are warranted.
有机氯（OC）农药是一组环境内分泌干扰物，可能与激素相关癌症（包括乳腺癌和前列腺癌）的风险增加有关。然而，流行病学证据有限且不一致。
我们使用 1999-2004 年全国健康和营养调查数据，研究 OC 农药血清浓度与前列腺癌和乳腺癌之间的关系。
在调整其他协变量后，β-六氯环己烷（HCH）（p 趋势=0.02）、反式-十氯酮（p 趋势=0.002）和狄氏剂（p 趋势=0.04）的血清浓度与现患前列腺癌的风险显著相关。可检测值的第二和第三三分位的调整比值比分别为 1.46（95%可信区间，0.52-4.13）和 3.36（95%可信区间，1.24-9.10）β-HCH；5.84（95%可信区间，1.06-32.2）和 14.1（95%可信区间，2.55-77.9）反式-十氯酮；1.06（95%可信区间，0.30-3.73）和 2.74（95%可信区间，1.01-7.49）狄氏剂与最低三分位或低于检测限的浓度相比。然而，OC 农药血清浓度与乳腺癌患病率之间没有正相关关系。
尽管需要进一步研究来证实这些发现，但这些结果表明 OC 农药暴露可能对癌症风险有显著影响。有必要努力减少全球 OC 的使用。
