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基于纳米棒-纳米颗粒结的 SERS 适体传感器用于蛋白质检测。

SERS aptasensor from nanorod-nanoparticle junction for protein detection.

机构信息

Physiological Sensing Facility, Bindley Biosciences Center and Birck Nanotechnology Center, Purdue University 225 S. University Street, 215 ABE Building, West Lafayette, IN 47907, USA.

出版信息

Chem Commun (Camb). 2010 Jan 28;46(4):613-5. doi: 10.1039/b919607b. Epub 2009 Nov 18.

DOI:10.1039/b919607b
PMID:20062879
Abstract

A multicomponent nanostructure comprising of gold nanorod-nanoparticle (AuNR-AuNP) composites was fabricated to detect thrombin at subnanomolar concentrations in diluted human blood serum. Simulation and experiments revealed that the strong electromagnetic coupling resonance at the nanorod-nanoparticle junction of these probes can be used to construct highly sensitive SERS aptasensors.

摘要

一种由金纳米棒-纳米颗粒（AuNR-AuNP）复合材料组成的多组分纳米结构被制备用于在稀释的人血清中检测亚纳摩尔浓度的凝血酶。模拟和实验表明，这些探针在纳米棒-纳米颗粒连接处的强电磁耦合共振可用于构建高灵敏度的 SERS 适体传感器。

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