The New Zealand Institute for Plant and Food Research Limited, Christchurch, New Zealand.
Br J Nutr. 2010 Apr;103(7):1023-8. doi: 10.1017/S0007114509992777. Epub 2010 Jan 12.
Honey is an established traditional medicine with a variety of putative nutritional and health effects, including antibacterial, antioxidant, anti-inflammatory and prebiotic. The aim of the present study was to investigate the safety of consuming manuka honey, UMF 20+, on healthy individuals by establishing whether UMF 20+caused an allergic response (as measured by IgE levels), changed major commensal and beneficial microbial groups in the gut and/or affected levels of one of the most common advanced glycation endpoints, N-(carboxymethyl)-lysine (CML). The study had a randomised, double-blind cross-over design. A total of twenty healthy individuals aged 42-64 years were recruited. We tested two different honeys- a multiflora honey and UMF 20+, both produced by Comvita New Zealand Ltd (Te Puke, New Zealand). Multiflora honey or UMF 20+(20 g) was consumed daily for 4 weeks, with a 2-week 'washout' period in between. Blood samples were collected every week for each intervention period and used to measure total IgE levels in serum and advanced glycation endproducts - a consequence of methyglyoxal accumulation. Faecal samples were collected at the beginning and end of each 4-week period. DNA was extracted from faecal samples and the levels of a number of microbial groups in the gut, both beneficial and commensal, were analysed. Neither product changed the levels of IgE or CML or altered gut microbial profiles during the trial, confirming that UMF 20+is safe for healthy individuals to consume. Despite anecdotal evidence suggesting that manuka honey is good for digestive health, we observed no beneficial effects on lower gut bacterial levels with either honey in this healthy population.
蜂蜜是一种传统的医药，具有多种潜在的营养和健康功效，包括抗菌、抗氧化、抗炎和益生元。本研究旨在通过确定 UMF 20+是否引起过敏反应（通过 IgE 水平测量）、是否改变肠道中的主要共生有益微生物群，以及是否影响最常见的晚期糖基化终产物之一 N-（羧甲基）赖氨酸（CML）的水平，来研究食用麦卢卡蜂蜜 UMF 20+对健康个体的安全性。该研究采用随机、双盲交叉设计。共招募了 20 名年龄在 42-64 岁的健康个体。我们测试了两种不同的蜂蜜-一种是多花蜜，另一种是 UMF 20+，均由 Comvita New Zealand Ltd（新西兰特普克）生产。多花蜜或 UMF 20+（20 克）每天食用，中间间隔 2 周的洗脱期。在每个干预期的每周采集血液样本，用于测量血清中的总 IgE 水平和晚期糖基化终产物-甲基乙二醛积累的结果。在每个 4 周周期的开始和结束时收集粪便样本。从粪便样本中提取 DNA，并分析肠道中有益和共生的许多微生物群的水平。在试验过程中，两种产品都没有改变 IgE 或 CML 的水平，也没有改变肠道微生物谱，这证实 UMF 20+对健康个体是安全的。尽管有传闻证据表明麦卢卡蜂蜜对消化健康有益，但我们在这个健康人群中没有观察到任何蜂蜜对下肠道细菌水平的有益影响。
