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本文引用的文献

1
Frequency of paradoxical effect with caspofungin in Candida albicans.卡泊芬净对白色念珠菌产生矛盾效应的频率。
Eur J Clin Microbiol Infect Dis. 2009 Jun;28(6):717. doi: 10.1007/s10096-008-0688-y. Epub 2009 Jan 8.
2
Multilocus sequence typing of pathogenic Candida species.致病性念珠菌属的多位点序列分型
Eukaryot Cell. 2008 Jul;7(7):1075-84. doi: 10.1128/EC.00062-08. Epub 2008 May 2.
3
Stimulation of chitin synthesis rescues Candida albicans from echinocandins.几丁质合成的刺激可使白色念珠菌免受棘白菌素的影响。
PLoS Pathog. 2008 Apr 4;4(4):e1000040. doi: 10.1371/journal.ppat.1000040.
4
Paradoxical growth effects of the echinocandins caspofungin and micafungin, but not of anidulafungin, on clinical isolates of Candida albicans and C. dubliniensis.棘白菌素类药物卡泊芬净和米卡芬净（而非阿尼芬净）对白色念珠菌和都柏林念珠菌临床分离株具有矛盾的生长效应。
Eur J Clin Microbiol Infect Dis. 2008 Feb;27(2):127-31. doi: 10.1007/s10096-007-0411-4. Epub 2007 Dec 4.
5
A Paradoxical Zone Phenomenon in the Bactericidal Action of Penicillin in Vitro.青霉素体外杀菌作用中的一种矛盾性区域现象。
Science. 1948 Jan 9;107(2767):44-5. doi: 10.1126/science.107.2767.44.
6
Acquired resistance to echinocandins in Candida albicans: case report and review.白色念珠菌对棘白菌素的获得性耐药：病例报告及文献复习
J Antimicrob Chemother. 2007 Jun;59(6):1076-83. doi: 10.1093/jac/dkm095. Epub 2007 Apr 27.
7
Paradoxical effect of Echinocandins across Candida species in vitro: evidence for echinocandin-specific and candida species-related differences.棘白菌素对念珠菌属的体外矛盾效应：棘白菌素特异性及念珠菌属相关差异的证据
Antimicrob Agents Chemother. 2007 Jun;51(6):2257-9. doi: 10.1128/AAC.00095-07. Epub 2007 Apr 16.
8
Candida albicans and Candida dubliniensis respond differently to echinocandin antifungal agents in vitro.白色念珠菌和都柏林念珠菌在体外对棘白菌素类抗真菌药物的反应不同。
Antimicrob Agents Chemother. 2007 May;51(5):1882-4. doi: 10.1128/AAC.01525-06. Epub 2007 Feb 16.
9
Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.在高于最低抑菌浓度（矛盾效应）的浓度下，念珠菌通过增加细胞壁几丁质而逃避卡泊芬净的抑制作用；卡泊芬净抑制β-1,6-葡聚糖合成的证据。
Antimicrob Agents Chemother. 2006 Sep;50(9):3160-1. doi: 10.1128/AAC.00563-06.
10
Assessment of the paradoxical effect of caspofungin in therapy of candidiasis.卡泊芬净治疗念珠菌病时矛盾效应的评估。
Antimicrob Agents Chemother. 2006 Apr;50(4):1293-7. doi: 10.1128/AAC.50.4.1293-1297.2006.

当接触卡泊芬净时，白色念珠菌的滞后或矛盾生长与微卫星基因型无关。

Trailing or paradoxical growth of Candida albicans when exposed to caspofungin is not associated with microsatellite genotypes.

机构信息

Laboratoire de Biologie Moléculaire Parasitaire et Fongique, Faculté de Médecine de Sfax, Sfax, Tunisia.

出版信息

Antimicrob Agents Chemother. 2010 Mar;54(3):1365-8. doi: 10.1128/AAC.00530-09. Epub 2010 Jan 11.

DOI:10.1128/AAC.00530-09
PMID:20065050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2825996/
Abstract

Multilocus microsatellite polymorphisms in 27 clinical Candida albicans isolates were found to be clearly unrelated to in vitro paradoxical growth or trailing effect with caspofungin. These findings suggest that such in vitro phenotypes are either gained or lost too rapidly to be predicted by more stable genomic markers.

摘要

对 27 株临床白色念珠菌分离株的多位点微卫星多态性研究发现，与体外反常生长或与卡泊芬净的拖尾效应明显无关。这些发现表明，这些体外表型要么获得或丢失得太快，无法用更稳定的基因组标记来预测。