Al Ghadeer Hussain A, AlRamadan Mohammed S, Al Amer Mohammed M, Alshawaf Meshal J, Alali Fatimah J, Bubshait Aisha A, Alramadhan Maryam A, Almurayhil Zainab, Aldandan Nasser S, AlKhamis Mohammed A, AlHaddad Habeeb A, AlOmair Abdulatif
Paediatrics, Maternity and Children Hospital, AlAhsa, SAU.
Internal Medicine, King Faisal University, AlAhsa, SAU.
Cureus. 2022 Feb 24;14(2):e22558. doi: 10.7759/cureus.22558. eCollection 2022 Feb.
Background and objective Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia. It is linked with an increase in morbidity (e.g., blindness, kidney failure, stroke, cardiovascular diseases, limb amputations), premature mortality, high healthcare costs, and is quickly becoming a global epidemic disorder. Several studies have shown that vitamin D supplements reduce insulin resistance in T2DM and improve insulin secretion and sensitivity. In this study, we aimed to determine the prevalence of vitamin D deficiency in T2DM patients in Saudi Arabia. Methods This was a retrospective cross-sectional study conducted at the King Faisal University Health Centre in Saudi Arabia. The study used patient data during the period from October 2014 to January 2021. After obtaining approval from the King Faisal University Polyclinic Administration, we collected patient data from the King Faisal University Health Centre. The Ethics and Research Committee at the College of Medicine of King Faisal University granted ethical approval with the approval number (2020-11-82). The relevant patient data were collected, including age, gender, nationality, and blood test findings (vitamin D and HbA1c levels). Results A total of 191 T2DM patients participated in this study. The mean age of the patients was 56.1 ± 11.4 years (range: 21-85 years); 107 (56%) patients were females, and 137 (71.7%) were Saudis. There were 134 (70.2%) patients with vitamin D deficiency, 53 (27.7%) with vitamin D insufficiency, and only four (2.1%) with normal vitamin D levels. Conclusion Based on our findings, the prevalence of vitamin D deficiency among T2DM patients is highly associated with poor diabetic control.
背景与目的 2型糖尿病(T2DM)是一种以高血糖为特征的慢性代谢紊乱疾病。它与发病率增加(如失明、肾衰竭、中风、心血管疾病、肢体截肢)、过早死亡、高医疗成本相关,并且正迅速成为一种全球性的流行疾病。多项研究表明,补充维生素D可降低T2DM患者的胰岛素抵抗,并改善胰岛素分泌和敏感性。在本研究中,我们旨在确定沙特阿拉伯T2DM患者中维生素D缺乏的患病率。
方法 这是一项在沙特阿拉伯法赫德国王大学健康中心进行的回顾性横断面研究。该研究使用了2014年10月至2021年1月期间的患者数据。在获得法赫德国王大学综合诊所管理部门的批准后,我们从法赫德国王大学健康中心收集了患者数据。法赫德国王大学医学院的伦理与研究委员会批准了该研究,批准号为(2020 - 11 - 82)。收集了相关患者数据,包括年龄、性别、国籍和血液检测结果(维生素D和糖化血红蛋白水平)。
结果 共有191例T2DM患者参与了本研究。患者的平均年龄为56.1±11.4岁(范围:21 - 85岁);107例(56%)患者为女性,137例(71.7%)为沙特人。有134例(70.2%)患者维生素D缺乏,53例(27.7%)维生素D不足,只有4例(2.1%)维生素D水平正常。
结论 根据我们的研究结果,T2DM患者中维生素D缺乏的患病率与糖尿病控制不佳高度相关。