Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA, USA.
Org Biomol Chem. 2010 Jan 21;8(2):299-304. doi: 10.1039/b913064k. Epub 2009 Nov 2.
Cell adhesions to both soluble and insoluble extracellular matrix ligands are critical in inter and intra-cellular signaling that mediates numerous physiological processes. These adhesions are complex structures composed of many scaffolding and signaling proteins. There are four distinct types of cell-matrix adhesions: focal complexes, focal adhesions, fibrillar adhesions, and 3D cell-matrix adhesions, which vary in composition, organization and function. The primary mediators of cell-matrix adhesions are integrins, which are mechanosensitive transmembrane receptor proteins that directly bind to matrix ligands to initiate adhesion formation. The development of cell-matrix adhesions is affected by a number of factors including matrix properties such as dimensionality and rigidity, and forces, both internally and externally generated, exerted on the adhesion sites. In this article, we discuss how matrix mechanics and forces affect the assembly and maturation of cell-matrix adhesions.
细胞与可溶性和不可溶性细胞外基质配体的黏附对于细胞内和细胞间信号转导至关重要，这种信号转导介导了许多生理过程。这些黏附是由许多支架和信号蛋白组成的复杂结构。细胞-基质黏附有四种不同的类型：焦点复合物、焦点黏附、纤维黏附和 3D 细胞-基质黏附，它们在组成、组织和功能上有所不同。细胞-基质黏附的主要介质是整合素，它是一种机械敏感的跨膜受体蛋白，直接与基质配体结合，启动黏附形成。细胞-基质黏附的形成受到许多因素的影响，包括基质的性质，如维度和刚性，以及施加在黏附部位的内部和外部产生的力。在本文中，我们讨论了基质力学和力如何影响细胞-基质黏附的组装和成熟。
