识别有巨细胞病毒感染风险的妊娠。
Identification of pregnancies at risk from cytomegalovirus infection.
作者信息
de Silva L M, Kampfner G L, Lister C M, Tobin J O
出版信息
J Hyg (Lond). 1977 Dec;79(3):347-54. doi: 10.1017/s0022172400053183.
Abstract
The fluorescent antibody technique was used for the identification of specific cytomegalovirus IgM in the sera of twenty-four of 1065 unmarried pregnant women. Seventeen of them were followed to term and five infected infants were identified. Two other infants had CMV IgM in neonatal serum samples but virus excretion was not demonstrated. The congenital infection rate in this study was 5.3 per 1000 births by virus excretion and 7.9 per 1000 if cases with specific IgM are included; from previous studies a rate of 8.8 per 1000 was expected. The reasons for the lack of relationship between specific IgM in the mothers' serum and infected babies is discussed.
摘要
采用荧光抗体技术对1065名未婚孕妇中的24名孕妇血清中的特异性巨细胞病毒IgM进行鉴定。其中17名孕妇随访至足月，发现5名感染婴儿。另外两名婴儿的新生儿血清样本中检测到巨细胞病毒IgM，但未发现病毒排泄情况。本研究中，通过病毒排泄得出的先天性感染率为每1000例出生中有5.3例；若将检测到特异性IgM的病例包括在内，则为每1000例出生中有7.9例；根据以往研究，预期感染率为每1000例出生中有8.8例。文中讨论了母亲血清中特异性IgM与受感染婴儿之间缺乏关联的原因。
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