SAFOSO, Bern, Switzerland.
Epidemiol Infect. 2010 Sep;138(9):1242-51. doi: 10.1017/S0950268809991518. Epub 2010 Jan 13.
Traditionally, the routine artificial digestion test is applied to assess the presence of Trichinella larvae in pigs. However, this diagnostic method has a low sensitivity compared to serological tests. The results from artificial digestion tests in Switzerland were evaluated over a time period of 15 years to determine by when freedom from infection based on these data could be confirmed. Freedom was defined as a 95% probability that the prevalence of infection was below 0.0001%. Freedom was demonstrated after 12 years at the latest. A new risk-based surveillance approach was then developed based on serology. Risk-based surveillance was also assessed over 15 years, starting in 2010. It was shown that by using this design, the sample size could be reduced by at least a factor of 4 when compared with the traditional testing regimen, without lowering the level of confidence in the Trichinella-free status of the pig population.
传统上,常规的人工消化试验用于评估猪体内旋毛虫幼虫的存在。然而,与血清学试验相比,这种诊断方法的灵敏度较低。对瑞士 15 年来人工消化试验的结果进行了评估,以确定根据这些数据何时可以确认无感染。无感染的定义是感染率低于 0.0001%的概率为 95%。最迟在 12 年后证明了无感染。然后,根据血清学开发了一种新的基于风险的监测方法。基于风险的监测也在 2010 年开始的 15 年内进行了评估。结果表明,与传统的测试方案相比,使用这种设计可以将样本量减少至少 4 倍,而不会降低对猪群无旋毛虫状态的置信度。