Muse K E, Collier A M, Baseman J B
J Infect Dis. 1977 Dec;136(6):768-77. doi: 10.1093/infdis/136.6.768.
Hamster tracheal organculture was employed as a model for the study of the pathogenesis of infection due to bordetella pertusis. Scanning electron microscopy provided a three-dimensional view of the surface infection of the tracheal explants. Phase I B. pertussis attached only to the ciliated epithelial cells, and a sequence of events involving the injury, expulsion, and destruction of these differentiated cells occurred. This in vitro model provides insights into the mechanisms by which B. pertussis mediates host cell injury at the site of infection.
仓鼠气管器官培养被用作研究百日咳博德特氏菌感染发病机制的模型。扫描电子显微镜提供了气管外植体表面感染的三维视图。第一阶段，百日咳博德特氏菌仅附着于纤毛上皮细胞，随后发生了一系列涉及这些分化细胞损伤、排出和破坏的事件。这个体外模型为百日咳博德特氏菌在感染部位介导宿主细胞损伤的机制提供了见解。
