The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA.
Annu Rev Public Health. 2010;31:53-68. doi: 10.1146/annurev.publhealth.031809.130844.
All diseases have a genetic predisposition. Genome-wide association studies (GWASs) by large international consortia are discovering genetic variants that contribute to complex diseases. However, nutrient information is missing, which is essential for the development of dietary advice for prevention and management of disease. Nutrigenetics/nutrigenomics studies provide data on mechanisms of nutrient and gene interactions in health and disease needed for personalized nutrition. A process will be needed to define when gene-nutrient-disease associations are ready to be evaluated as potential tools to improve public health.
所有疾病都有遗传易感性。大型国际联盟进行的全基因组关联研究(GWAS)正在发现导致复杂疾病的遗传变异。然而,目前缺少营养信息,这对于制定预防和管理疾病的饮食建议至关重要。营养遗传学/营养基因组学研究为个性化营养提供了有关营养和基因相互作用在健康和疾病中的机制的数据。需要一个过程来定义何时基因-营养-疾病关联可以作为改善公共健康的潜在工具进行评估。