Augenklinik rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 Munich, Germany.
Graefes Arch Clin Exp Ophthalmol. 2010 Mar;248(3):409-13. doi: 10.1007/s00417-009-1270-8.
To assess the influence of age-related macular degeneration (AMD) on critical flicker-fusion frequency (CFF).
CFF was measured centrally for a red, green and blue target, and in 10 degrees excentricity with a red target. Twenty-eight patients with non-exsudative AMD, 12 patients with exsudative AMD and 45 age-matched healthy eyes were included.
CFF decreased in eyes with non-exsudative AMD (red 1.3 Hz, p=0.025; green 1.4 Hz, p=0.053; blue 2.1 Hz, p=0.006) and exsudative AMD (red 2.2 Hz, p=0.02; green 3.3 Hz, p=0.001; blue 2.9 Hz, p=0.02). The difference between central and peripheral CFF increased in non-exsudative AMD (red-red 10 degrees, 0.7 Hz, p=0.024), but was not significantly increased in exsudative AMD (1.3 Hz, p=0.059). There was no difference between eyes with non-exsudative AMD with good visual acuity (VA >20/32, n=18) and healthy eyes, nor between eyes with non-exsudative (n=10) and exsudative AMD (n=9) with VA from 20/100 to 20/40.
CFF decreased in non-exsudative and exsudative AMD. CFF is not able to distinguish between AMD eyes and healthy eyes of equal visual acuity, and therefore is not applicable as a possible diagnostic test.
评估年龄相关性黄斑变性（AMD）对视功能关键闪烁融合频率（CFF）的影响。
对 28 例非渗出性 AMD 患者、12 例渗出性 AMD 患者和 45 例年龄匹配的健康眼进行了中央和 10 度偏心的红色、绿色和蓝色靶标 CFF 测量。
非渗出性 AMD 眼（红色 1.3 Hz，p=0.025；绿色 1.4 Hz，p=0.053；蓝色 2.1 Hz，p=0.006）和渗出性 AMD 眼（红色 2.2 Hz，p=0.02；绿色 3.3 Hz，p=0.001；蓝色 2.9 Hz，p=0.02）的 CFF 降低。非渗出性 AMD 中央和周边 CFF 的差值增加（红色-10 度，0.7 Hz，p=0.024），但渗出性 AMD 无显著增加（1.3 Hz，p=0.059）。视力较好（VA>20/32，n=18）的非渗出性 AMD 眼与健康眼之间，以及非渗出性 AMD（n=10）与渗出性 AMD（n=9）眼之间的 VA 为 20/100 至 20/40 时，CFF 均无差异。
非渗出性和渗出性 AMD 患者的 CFF 降低。CFF 不能区分 AMD 眼和具有相同视力的健康眼，因此不能作为可能的诊断测试。
