Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Nat Prod Res. 2010;24(2):152-9. doi: 10.1080/14786410902941097.
A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(-)-cornigerine (5), along with four known compounds, but new to the species: (-)-colchicine (1), (-)-demecolcine (2), (-)-N-methyl-(-)-demecolcine (3) and 3-demethyl-N-methyl-(-)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel.
从番红花（Colchicum crocifolium Boiss.）（秋水仙科）中分离得到一种新的秋水仙碱类似物，并鉴定为 N,N-二甲基-N-去乙酰基-(-)-cornigerine（5），以及另外四种已知化合物，但在该物种中为新化合物：(-)-秋水仙碱（1）、(-)-去甲秋水仙碱（2）、(-)-N-甲基-(-)-去甲秋水仙碱（3）和 3-去甲基-N-甲基-(-)-去甲秋水仙碱（4）。所有分离得到的化合物对人癌细胞系均显示出很强的细胞毒性。
