衰老研究中与健康和疾病相关的生物标志物。
Health-and disease-related biomarkers in aging research.
作者信息
Thompson Hilaire J, Voss Joachim G
机构信息
The University of Washington, Biobehavioral Nursing and Health Systems, Box 357266, Seattle, WA 98195-7266, USA.
出版信息
Res Gerontol Nurs. 2009 Apr;2(2):137-48. doi: 10.3928/19404921-20090401-09.
This article focuses on a synthesis of knowledge about healthy aging research in human beings and then synthesized nurse-led research in gerontology and geriatrics that use biomarkers. Healthy aging research has attracted considerable attention in the biomedical and basic sciences within the context of four major areas: (a) genetic variations as an expression of successful or unsuccessful aging; (b) caloric restriction as an intervention to slow the progression of aging; (c) immunological aging; (d) neurobiology of the aging brain. A systematic review of the literature was performed to identify nurse-led geriatric-related biomarker research. Nurse researchers who have chosen to integrate biomarkers as part of their research studies have been working in six focal areas, which are reviewed: health promotion within risk populations, cancer, vascular disease, Alzheimer's disease, caregiving, and complementary therapies. The article provides a discussion of contributions to date, identifying existing gaps and future research opportunities.
本文着重综合了关于人类健康老龄化研究的知识，然后综合了老年学和老年医学领域中由护士主导的使用生物标志物的研究。在四个主要领域的背景下，健康老龄化研究在生物医学和基础科学领域引起了相当大的关注：（a）作为成功或不成功衰老表现的基因变异；（b）热量限制作为减缓衰老进程的干预措施；（c）免疫衰老；（d）衰老大脑的神经生物学。对文献进行了系统综述，以确定由护士主导的与老年医学相关的生物标志物研究。选择将生物标志物纳入其研究的护士研究人员一直在六个重点领域开展工作，本文将对这些领域进行综述：风险人群中的健康促进、癌症、血管疾病、阿尔茨海默病、护理以及补充疗法。本文讨论了迄今为止的贡献，指出了现有差距和未来的研究机会。
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