Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1249-59. doi: 10.1152/ajpheart.00363.2009. Epub 2010 Jan 15.
The availability of detailed three-dimensional images of vascular trees from mammalian organs provides a wealth of essential data for understanding the processes and mechanisms of vascular patterning. Using this detailed geometric data requires the ability to compare individual representations of vascular trees in statistically meaningful ways. This article provides some comparisons of geometry and also of simulated hemodynamics, enabling the identification of similarities and differences among 10 individual specimens (5 placenta specimens and 5 lung specimens). Similar comparisons made with a series of models (starting with the simplest and increasing in complexity) enable the identification of essential features that are needed to account for the patterns and function of vascular arborization.
哺乳动物器官中详细的血管树三维图像的可用性为理解血管模式形成的过程和机制提供了丰富的重要数据。使用这种详细的几何数据需要以具有统计意义的方式比较血管树的个体表示。本文提供了一些几何形状和模拟血液动力学的比较，从而能够识别 10 个个体标本（5 个胎盘标本和 5 个肺标本）之间的相似点和不同点。通过与一系列模型（从最简单的模型开始，然后逐渐增加复杂性）进行类似的比较，可以确定为解释血管分支的模式和功能所需的基本特征。
