Jacobs J W, Rasker J J, Van Riel P L, Gribnau F W, van de Putte L B
Academisch Ziekenhuis, afd. Reumatologie, Utrecht.
Ned Tijdschr Geneeskd. 1991 Feb 23;135(8):317-22.
To evaluate the effectiveness of several types of complementary medicine in patients with rheumatic diseases, a literature search was performed. Clinical trials, blind or open, comparing the effectiveness of forms of complementary medicine with that of placebo or another control therapy in patients with rheumatoid arthritis, osteoarthritis, soft tissue rheumatism and the fibromyalgia syndrome were selected until half of 1989, using electronic databases. Abstracts and summaries were excluded. The investigation was performed at the department of rheumatology of the Medisch Spectrum Twente hospital at Enschede in cooperation with the department of internal diseases of the Sint Radboud hospital at Nijmegen. For each type of complementary treatment, the results of all the clinical trials were summarized. Furthermore, the placebo-controlled trials were graded according to convincing trials or trials that seemed to be less valid and/or difficult to interpret. Data concerning acupuncture, balneotherapy, dietary measures, enzymic therapy, Seatone, homeopathy, manual therapy and fever few were found. Of these types of complementary medicine in rheumatic diseases, we found no convincing prove that they are more effective than the control or placebo treatment. A considerable number of the studies however can be criticized. It is necessary to perform further studies on the effect of frequently used types of complementary medicine in patients with rheumatic diseases, by or in cooperation with the physicians or paramedics who prescribe or perform these kinds of treatment. This is nearly always possible; directives are given to realize further studies of this kind. If a particular treatment proves to be no more effective than placebo treatment, its use should be discouraged.
为评估几种补充替代医学对风湿病患者的疗效,我们进行了文献检索。利用电子数据库,选取了截至1989年6月的临床试验(包括盲法或开放试验),这些试验比较了补充替代医学形式与安慰剂或其他对照疗法对类风湿关节炎、骨关节炎、软组织风湿病和纤维肌痛综合征患者的疗效。排除了摘要和综述。该研究由恩斯赫德的Medisch Spectrum Twente医院风湿病科与奈梅亨的圣拉德布德医院内科合作进行。对于每种补充替代疗法,总结了所有临床试验的结果。此外,将安慰剂对照试验根据可信度高的试验或似乎有效性较低和/或难以解释的试验进行分级。找到了关于针灸、水疗、饮食措施、酶疗法、Seatone、顺势疗法、手法治疗和发热疗法的数据。在这些用于治疗风湿病的补充替代医学类型中,我们没有找到令人信服的证据表明它们比对照或安慰剂治疗更有效。然而,相当数量的研究可能受到批评。有必要由开处方或实施这类治疗的医生或医护人员单独或合作,对常用的补充替代医学类型对风湿病患者的疗效进行进一步研究。这几乎总是可行的;已给出指导方针以实现这类进一步研究。如果某一特定治疗被证明并不比安慰剂治疗更有效,则应不鼓励使用。