Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Euro Surveill. 2010 Jan 14;15(2):19461. doi: 10.2807/ese.15.02.19461-en.
We analysed and reported on a weekly basis clinical and epidemiological characteristics of patients hospitalised in the Netherlands for the 2009 pandemic influenza A(H1N1) using information from the national mandatory notification system. The notification criteria changed on 15 August 2009 from all possible, probable and confirmed cases to only laboratory-confirmed pandemic influenza hospitalisations and deaths. In the period of comprehensive case-based surveillance (until 15 August), 2% (35/1,622) of the patients with pandemic influenza were hospitalised. From 5 June to 31 December 2009, a total of 2,181 patients were hospitalised. Of these, 10% (219/2,181) were admitted to an intensive care unit (ICU) and 53 died. Among non-ICU hospitalised patients, 56% (961/1,722) had an underlying medical condition compared with 70% (147/211) of the patients in ICU and 46 of the 51 fatal cases for whom this information was reported. Most common complications were dehydration among non-ICU hospitalised patients and acute respiratory distress syndrome among patients in ICU and patients who died. Children under the age of five years had the highest age-specific hospitalisation rate (62.7/100,000), but relatively few were admitted to an ICU (1.7/100,000). Characteristics and admission rates of hospitalised patients were comparable with reports from other countries and previous influenza seasons. The national notification system was well suited to provide weekly updates of relevant monitoring information on the severity of the pandemic for professionals, decision makers, the media and the public, and could be rapidly adapted to changing information requirements.
我们每周分析和报告荷兰因 2009 年大流行流感 A(H1N1)住院的患者的临床和流行病学特征,使用国家强制性报告系统提供的信息。从 2009 年 8 月 15 日起,通知标准从所有可能、疑似和确诊病例改为仅报告实验室确诊的大流行流感住院和死亡病例。在全面基于病例的监测期间(截至 8 月 15 日),2%(35/1622)的大流行流感患者住院。从 2009 年 6 月 5 日至 12 月 31 日,共有 2181 名患者住院。其中,10%(219/2181)入住重症监护病房(ICU),53 人死亡。在非 ICU 住院患者中,56%(961/1722)有基础疾病,而 ICU 患者中这一比例为 70%(147/211),报告信息的 51 例死亡病例中这一比例为 46%。最常见的并发症是非 ICU 住院患者的脱水和 ICU 患者以及死亡患者的急性呼吸窘迫综合征。五岁以下儿童的年龄特异性住院率最高(62.7/100000),但相对较少的患者入住 ICU(1.7/100000)。住院患者的特征和入院率与其他国家和以往流感季节的报告相似。国家报告系统非常适合为专业人员、决策者、媒体和公众提供有关大流行严重程度的每周监测信息更新,并且能够快速适应不断变化的信息需求。