Adams Jonathan D, Thévoz Patrick, Bruus Henrik, Soh H Tom
Appl Phys Lett. 2009 Dec 21;95(25):254103. doi: 10.1063/1.3275577.
With a growing number of cell-based biotechnological applications, there is a need for particle separation systems capable of multiparameter separations at high purity and throughput, beyond what is presently offered by traditional methods including fluorescence activated cell sorting and column-based magnetic separation. Toward this aim, we report on the integration of microfluidic acoustic and magnetic separation in a monolithic device for multiparameter particle separation. Using our device, we demonstrate high-purity separation of a multicomponent particle mixture at a throughput of up to 10(8) particleshr.
随着基于细胞的生物技术应用越来越多，需要一种能够以高纯度和高通量进行多参数分离的颗粒分离系统，这超出了包括荧光激活细胞分选和基于柱的磁分离在内的传统方法目前所能提供的范围。为了实现这一目标，我们报告了一种用于多参数颗粒分离的整体式装置中微流控声学和磁分离的集成。使用我们的装置，我们展示了在高达10⁸个颗粒/小时的通量下对多组分颗粒混合物进行高纯度分离。
