在一项大型国际研究中，人乳头瘤病毒与结直肠癌无关。
Human papillomavirus is not associated with colorectal cancer in a large international study.
机构信息
Department of Human Genetics, School of Medicine, University of Michigan, 109 Zina Pitcher, Ann Arbor, MI 48109-2200, USA.
出版信息
Cancer Causes Control. 2010 May;21(5):737-43. doi: 10.1007/s10552-010-9502-0. Epub 2010 Jan 20.
Abstract
OBJECTIVE OF THE STUDY
Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer.
METHODS
The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15).
RESULTS
All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method.
CONCLUSIONS
We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.
摘要
研究目的
最近的出版物报道了结肠癌与人类乳头瘤病毒（HPV）之间的关联，提示结肠黏膜的 HPV 感染可能有助于结直肠癌的发展。
方法
使用 GP5+/GP6+PCR 反向线印迹法检测石蜡包埋或冷冻组织中 37 种人乳头瘤病毒（HPV），包括来自美国（n=73）、以色列（n=106）和西班牙（n=100）的三个不同研究人群的 279 例结直肠癌患者和 30 例正常相邻组织的 DNA。此外，对所有样本（n=279）进行 SPF10PCR 检测，对部分样本（n=15）进行 Innogenetics INNO-LiPA 检测。
结果
使用 GP5+/GP6+PCR 反向线印迹法和 SPF10 INNO-LiPA 法，所有样本均为 HPV 阴性。
结论
我们得出结论，与恶性转化相关的 HPV 类型对结肠腺癌没有明显贡献。
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