Troxler D H, Lowy D, Howk R, Young H, Scolnick E M
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4671-5. doi: 10.1073/pnas.74.10.4671.
The spleen focus-forming virus (SFFV), a replication-defective murine leukemia virus that causes the rapid transformation of certain hematopoietic target cells, has acquired specific xenotropic viral genetic information not contained in Friend helper virus. In the current studies, it is shown that a cDNA that represents a xenotropic virus portion of SFFV detects genetic sequences derived from the env gene region of murine xenotropic virus. The significance of the acquisition of these xenotropic viral sequences by SFFV is discussed with regard to their possible role in the rapid leukemogenicity of SFFV, and an analogy is drawn between the formation of SFFV and the formation of the Kirsten and Harvey sarcoma viruses.
脾集落形成病毒(SFFV)是一种复制缺陷型鼠白血病病毒,可导致某些造血靶细胞迅速转化,它获得了弗氏辅助病毒中所没有的特定嗜异性病毒遗传信息。在当前的研究中,结果表明,一个代表SFFV嗜异性病毒部分的cDNA可检测到源自鼠嗜异性病毒env基因区域的遗传序列。文中讨论了SFFV获得这些嗜异性病毒序列的意义,涉及其在SFFV快速致白血病性中可能发挥的作用,并对SFFV的形成与克里斯滕和哈维肉瘤病毒的形成进行了类比。