脾灶形成病毒的Friend毒株是嗜亲性鼠C型病毒与异嗜性C型病毒env基因区域之间的重组体。
Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus.
作者信息
Troxler D H, Lowy D, Howk R, Young H, Scolnick E M
出版信息
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4671-5. doi: 10.1073/pnas.74.10.4671.
Abstract
The spleen focus-forming virus (SFFV), a replication-defective murine leukemia virus that causes the rapid transformation of certain hematopoietic target cells, has acquired specific xenotropic viral genetic information not contained in Friend helper virus. In the current studies, it is shown that a cDNA that represents a xenotropic virus portion of SFFV detects genetic sequences derived from the env gene region of murine xenotropic virus. The significance of the acquisition of these xenotropic viral sequences by SFFV is discussed with regard to their possible role in the rapid leukemogenicity of SFFV, and an analogy is drawn between the formation of SFFV and the formation of the Kirsten and Harvey sarcoma viruses.
摘要
脾集落形成病毒（SFFV）是一种复制缺陷型鼠白血病病毒，可导致某些造血靶细胞迅速转化，它获得了弗氏辅助病毒中所没有的特定嗜异性病毒遗传信息。在当前的研究中，结果表明，一个代表SFFV嗜异性病毒部分的cDNA可检测到源自鼠嗜异性病毒env基因区域的遗传序列。文中讨论了SFFV获得这些嗜异性病毒序列的意义，涉及其在SFFV快速致白血病性中可能发挥的作用，并对SFFV的形成与克里斯滕和哈维肉瘤病毒的形成进行了类比。
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Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus.脾灶形成病毒的Friend毒株是嗜亲性鼠C型病毒与异嗜性C型病毒env基因区域之间的重组体。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4671-5. doi: 10.1073/pnas.74.10.4671.
2
Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.脾脏集落形成病毒的Friend毒株：一种小鼠C型亲嗜性病毒序列与异嗜性病毒相关序列之间的重组体。
J Virol. 1977 May;22(2):361-72. doi: 10.1128/JVI.22.2.361-372.1977.
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Helper-independent mink cell focus-inducing strains of Friend murine type-C virus: potential relationship to the origin of replication-defective spleen focus-forming virus.弗氏鼠C型病毒的辅助非依赖型貂细胞集落诱导株：与复制缺陷型脾集落形成病毒起源的潜在关系
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Presence and expression of Friend erythroleukemia virus-related sequences in normal and leukemic mouse tissues.正常和白血病小鼠组织中Friend红白血病病毒相关序列的存在与表达。
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Type-specific radioimmunoassays for the gp70s of mink cell focus-inducing murine leukemia viruses: expression of a cross-reacting antigen in cells infected with the Friend strain of the spleen focus-forming virus.水貂细胞集落诱导型小鼠白血病病毒gp70的型特异性放射免疫测定：脾脏集落形成病毒Friend株感染细胞中一种交叉反应抗原的表达
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Analysis of integrated proviral DNA sequences with an octadecanucleotide probe designed for specific identification of spleen focus-forming virus in the mouse genome.用为在小鼠基因组中特异性鉴定脾集落形成病毒而设计的十八核苷酸探针分析整合的前病毒DNA序列。
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The Friend spleen focus-forming virus (SFFV) genome: fractionation and analysis of SFFV and helper virus-related sequences.Friend脾集落形成病毒（SFFV）基因组：SFFV及辅助病毒相关序列的分级分离与分析
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Requirement of the single base insertion at the 3' end of the env-related gene of Friend spleen focus-forming virus for pathogenic activity and its effect on localization of the glycoprotein product (gp55).Friend脾集落形成病毒env相关基因3'端单碱基插入对致病活性的要求及其对糖蛋白产物（gp55）定位的影响。
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Subgenomic fragment of molecular cloned Friend murine leukemia virus DNA contains the gene(s) responsible for Friend murine leukemia virus-induced disease.分子克隆的弗氏鼠白血病病毒DNA的亚基因组片段含有与弗氏鼠白血病病毒诱导疾病相关的基因。
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Fv-2 locus controls expression of Friend spleen focus-forming virus-specific sequences in normal and infected mice.Fv-2基因座控制正常和感染小鼠中弗瑞德脾集落形成病毒特异性序列的表达。
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引用本文的文献
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J Virol. 1980 Mar;33(3):936-44. doi: 10.1128/JVI.33.3.936-944.1980.
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Envelope gene sequences which encode the gp52 protein of spleen focus-forming virus are required for the induction of erythroid cell proliferation.编码脾集落形成病毒gp52蛋白的包膜基因序列是诱导红细胞增殖所必需的。
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Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.具有白血病特征的疾病在成年瑞士小鼠中的无细胞传播。
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Ribonucleic acid isolated by cesium chloride centrifugation.通过氯化铯离心法分离得到的核糖核酸。
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Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses.核糖核酸肿瘤病毒逆转录酶的免疫学关系
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Isolation of murine sarcoma virus-transformed mouse cells which are negative for leukemia virus from agar suspension cultures.从琼脂悬浮培养物中分离白血病病毒呈阴性的鼠肉瘤病毒转化的小鼠细胞。
Int J Cancer. 1970 Jul 15;6(1):95-107. doi: 10.1002/ijc.2910060114.
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Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus.柯尔斯滕肉瘤病毒核酸序列的研究：一种含RNA的哺乳动物肉瘤病毒形成的模型。
J Virol. 1973 Sep;12(3):458-63. doi: 10.1128/JVI.12.3.458-463.1973.
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A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum.将人横纹肌肉瘤细胞接种到经抗胸腺细胞血清处理的NIH瑞士小鼠体内后发现的一种C型病毒。
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RNA in mammalian sarcoma virus transformed nonproducer cells homologous to murine leukemia virus RNA.与鼠白血病病毒RNA同源的哺乳动物肉瘤病毒转化的非产生细胞中的RNA。
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